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The interest in PM is growing since the complexity of its elements and consequences at different levels makes this paradigm a valuable tool for studying physiological, behavioral, motivational, rewarding, and plastic changes in a laboratory setting resembling natural conditions

The daily dose of short-term application of anthraquinones in adults to relieve constipation should be restrained within 30 mg/d and 23 times per week ( Statements Author contributions RD designed the study

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