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It must be practical to use: cost-effective easy to store and add to the feed
However, selenium should not be routinely supplemented in non-deficient individuals [55, 63], in particular because chronic excess may lead to toxicity (selenosis)
A known limitation is the lack of responsiveness and sensitivity of the EDSS to detect disability changes, especially in domains beyond motor dysfunction (Inojosa et al., 2020)
mTOR signaling in growth control and disease
