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2.3.3 Sphingosine-1-phosphate receptor 2: potential crosstalk with conjugated bile acids in TIME Beyond receptors primarily sensing unconjugated or secondary BAs, the G protein-coupled receptor Sphingosine-1-Phosphate Receptor 2 (S1PR2) represents another signaling node potentially linking BA metabolism to the TIME, primarily through interactions with conjugated bile acids (CBAs) (103)

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FAK-paxillin activation for fibroblast migration Growth hormone receptor upregulation on tendons VEGFR2-Akt-eNOS pathway for blood vessel formation Nitric oxide modulation reducing inflammation Erg-1 transcription factor inhibition Angiogenesis, the formation of new blood vessels, represents another critical mechanism

Murphy, K