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The scoring was determined and graded as absent=0, mild=1, moderate=2, or marked=3.12 Stereological analysis Stereological analyses were made using a stereology workstation consisting of stereology software (Stereo Investigator version 9.0, Microbrightfield, Colchester, VT, USA), a modified light microscope (Leica DM4000 B, Germany) and a motorized system which can move the section in both x and y direction

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