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Kanno A, Ishida K, Hamada S, et al

Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms

Metabolically constrained, potentially reversible dysfunction may be more amenable to strategies that restore mitochondrial fitness (e.g., redox modulation) and support lymphocyte recovery (e.g., IL-7/IL-15), whereas exhaustion-like states may require checkpoint modulation in combination with approaches that target upstream mitochondrial stress and the TOX/NR4Aepigenetic axis

PRP has been used safely for years in other fields of medicine, like orthopedics, and has a strong track record