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J Dermatolog Clin Res
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Originally designed to inhibit ALK phosphorylation by interacting with the Y1230 residue and causing G1/S-phase cell cycle arrest and apoptosis [106], Crizotinib also has potent activity against c-MET with exon 14 alterations
7 8 The decisive lesson is that human trials measure the endpoint that matters net weight and fat change in real people and at that bar the compound did not perform, regardless of how clean the upstream lipolysis readouts looked
