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Maintain mitochondrial function: p53 enhances the TCA cycle and oxidative phosphorylation through multiple mechanisms
Together, these findings underpin the significance of GJ-mediated retrograde communication in physiological and pathophysiological conditions
Furthermore, ribose-5-phosphate can also be derived from uridine (which in turn could be derived from salvage pathways and degradation of endogenous or exogenous RNA), and this has been shown to fuel glucose-restricted solid cancers 74
