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Receptors on the surface of the terminal ileum (the distal portion of the small intestine) take up the IF-B 12 complex only in the presence of calcium, which is supplied by the pancreas (6)

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Starting at 2.5mg weekly for four weeks, then escalating in 2.5mg increments every four weeks to minimize gastrointestinal side effects (nausea, vomiting, diarrhea)

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