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4.1.1 Riluzole Riluzole (2-amino-6-(trifluoromethoxy)benzothiazole) was developed to modulate glutaminergic transmission to target excess of the excitatory neurotransmitter, glutamate, at synapses in the central nervous system [109]
doi: 10.1007/s42804-025-00264-0 Luis Chiva SUROVA Study Group

Studies have shown that -PVP and mephedrone significantly increase microglial activation in the striatum, contributing to long-term neurodegeneration ( 5 Ketamine Ketamine, first synthesized in the 1960s as a safer alternative to phencyclidine for anesthesia, has gained widespread use as both a therapeutic agent and recreational drug

doi: 10.1046/j.1471-4159.1998.70062613.x
