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Pentosan polysulfate maculopathy

10.1016/j.redox.2023.102820 81 LommiJ.KupariM.KoskinenP.NaveriH.LeinonenH.PulkkiK.et al (1996)

Diabetic hyperglycemia further exacerbates this by suppressing astrocytic pentose phosphate pathway flux, which depletes nicotinamide adenine dinucleotide phosphate (NADPH) reserves [132, 133], a mechanism that mirrors defects in diabetic neuropathy where impaired redox defense amplifies oxidative injury

Additional clinical trials were identified by carefully reading the publication list of the identified articles