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Finally, SIRT1 promotes the transcriptional activity of Nuclear factor (erythroid-derived 2)-like 2 (NRF2)

Additionally, tumor necrosis factor-like weak inducer of apoptosis modulates senescence through SIRT1, reducing senescence-associated -galactosidase (SA--Gal) activity, a well-known marker of senescence (Zhang et al., 2017)

Stoeltzing et al (109) reported that IGF-I selectively upregulates COX-2 through the MAPK/(ERK1/2) pathway in pancreatic cancer and that treatment with anti-IGF-IR antibodies can effectively inhibit IGF-IR and MAPK/ERK activation and reduce COX-2 expression in parental cells

, 2018), regulating the concentration of cellular peroxides