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Although we are unable to directly assess site-specific LepR ICD phosphorylation with available reagents, these results indicate that phosphorylation of Tyr1141 may occur more efficiently than phosphorylation of Tyr986, such that reducing stability of the 2:2 complex more substantially impacts phosphorylation at Tyr986

-Eye Irritation, appearing as watery or bloodshot conditions, red and/or swollen eyelids, accumulated crusting around the eyelids or eyelashes

However, if left untreated, the condition can cause severe, long-lasting damage to the heart and brain, as well as other organs

Written by: Ana Untaroiu, M.D