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Chronic inflammation is a hallmark of metabolic syndrome, and anthocyanins (320 mg/day for 4 weeks) can lower systemic inflammation by inhibiting proinflammatory factors like TNF- and IL-6, thus alleviating metabolic syndrome symptoms (116, 117)

It is thus tempting to suggest that pore-regulating proteins operate to control the mitochondrial and nuclear GSH concentration in a manner similar to that observed in animal cells (Figure 5)

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The reason why lies in caffeine-intolerant individuals genes, which include a gene variant that produces a slowed down version of the liver enzyme responsible for metabolizing caffeine, so it can be cleared out of the body via the kidneys