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Receptor desensitization at a glance Main affected class Growth hormone secretagogues (CJC-1295, Ipamorelin, Sermorelin, Tesamorelin) Core mechanism Fewer receptors and/or faster receptor shutdown with chronic stimulation Typical fix 3 to 4 week break, or 5-on/2-off weekly pattern Usually not receptor-driven BPC-157, NAD+, MOTS-c, GHK-Cu, Thymosin Alpha-1 Wrong move Chasing fading effect by doubling the dose Deeper guide See the [peptide cycling chart](/blog/peptide-cycling-guide) for schedules by peptide The Signal vs