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In summary, GSHee and L-CYSee 21 may represent the first examples of a novel class of thiolester compounds that are able to effectively prevent the ventilatory depressant effects of powerful opioids such as fentanyl (and perhaps other high potency opioids such as sufentanil and alfentanil) and their deleterious effects on breathing stability and gas-exchange within the lungs without compromising the analgesic actions of the opioids

[DOI] [PubMed] [Google Scholar] FernndezMoncada, I

Pushing a normal man from 500 to 900 isn't doing what the marketing implies

The subsequent pharmacological characterization of L-lactate as a ligand for GPR81 was initiated, taking into account the similarity of GPR81 with other receptors from the GPR family, GPR109a and GPR109b, which also have -hydroxybutyrate as a ligand