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BPC 157 antagonized portal/caval hypertension (caval portal hypertension), and aortal hypotension, refractory ascites and thrombosis (portal vein tributaries, inferior vena cava, hepatic and coronary arteries), pathology of the lungs (severe capillary congestion) and liver (dilated central veins and terminal portal venules), intestine hemorrhagic lesions (substantial capillary congestion, submucosal edema and architecture loss), increased liver and spleen weight serum and enzymes values, NO- and MDA-levels in the liver

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Of these BDNF has received considerable attention regarding depression and stress [58] and AD [55,59,60]

Therapeutic opportunities with pharmacological inhibition of CD38 with isatuximab