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Clogging is a common cause of filter failure and owner frustration, and pre-filters significantly reduce both of these things
[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Smoday I.M., Krezic I., Kalogjera L., Vukovic V., Zizek H., Skoro M., Kovac K.K., Vranes H., Barisic I., Sikiric S., et al

Persistently high results could signal a blood disorder, a malignancy or a problem with the liver or kidneys

In its absence, peripheral neuropathy can occur, leading to numbness in your extremities