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Therapy must be responsive to these changing developmental demands

Recent studies have demonstrated that SGLT2 inhibitors trigger autophagy via the mammalian target of rapamycin (mTOR), 5adenosine monophosphate-activated protein kinase (AMPK), sirtuin 1 (SIRT1), and hypoxia-inducible factor (HIF) signaling pathways (257259)

[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Kinoshita C., Kikuchi-Utsumi K., Aoyama K., Suzuki R., Okamoto Y., Matsumura N., Omata D., Maruyama K., Nakaki T