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Description
In addition to thiol oxidation leading to disulfide bond formation by reactive oxygen species (ROS) (Suzuki et al, 2019), KEAP1 cysteine residues undergo S-alkylation by various endogenous and/or exogenous electrophiles (Wu and Papagiannakopoulos, 2020), such as succination by fumarate (Ooi et al, 2011

doi: 10.1155/2014/472459 177 PataniR.HardinghamG

W., Ansari, M

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