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Here, stimuli in the surrounding micro-environment induce macrophages to adopt pro-inflammatory or anti-inflammatory phenotypes and functions, thereby mediating inflammatory/autoimmune or homeostatic/reparative responses, respectively ( Macrophages are among the first cells to traffic to the pancreas under both physiological and diabetogenic conditions

Overall, the multifaceted role of GPX4 makes it an intriguing focal point for therapeutic interventions and demonstrates its potential to shape the future of cancer therapy

These effects occur through mechanisms including enhanced angiogenesis, modulation of growth factor expression, and direct cytoprotection of gastric epithelial cells

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