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In the phase 1b/2a clinical trial with amycretin, an unimolecular GLP-1, and amylin RA intended for OW SC use, the 125 individuals with overweight or obesity included in the study achieved an estimated body weight loss of 9.7% on 1.25 mg (20 weeks), 16.2% on 5 mg (28 weeks) and 22.0% on 20 mg following 36 weeks of treatment [127]

In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]