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Description
Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA
Furthermore, NADPH is replenished by the isocitrate dehydrogenase (IDH1/IDH2) branch of the citric acid cycle (TCA cycle), malic enzyme (ME1), and one-carbon metabolism (such as the folate cycle) depending on cell type or nutritional status
The GLUD1 gene encoded enzyme is the primary glutamate dehydrogenase (GDH1) activity in most tissues
Participants were provided with either a placebo or a daily antioxidant bar containing high doses of vitamin C (343 mg) and vitamin E (84 mg) during a period of six months
