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Cardiovasc Res 97, 282292, doi: 10.1093/cvr/cvs333 (2013)
Many UK laboratories now measure holotranscobalamin (active B12)
However, using benzoyl peroxide and retinol (this includes prescription-strength tretinoin) in the same routine is counterproductive as the two ingredients neutralize each other, decreasing their effectiveness
The high sensitivity but lower specificity of the HepG2 cell model with hamster S9-mix therefore makes the model useful when a conservative approach to avoid false-negative results is the goal of the test strategy
