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This is certainly related to the central role of autophagy as the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the lysosome ( In general, the definition of the term autophagy refers to the main subtype of the process, macroautophagy, which represents the most widespread form

In this review, we emphasize on (1) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (2) importance of oxidative stress and antioxidants in SARS-CoV-2 infection and COVID-19 disease, (3) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (4) new therapies that include antioxidant defenses restoration

8.0 to 8.7 kcal/mol) drives it strongly in the forward direction