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Glutathione peroxidase isozyme 4 (GPX4) is an enzyme capable of detoxifying alkyl-hydroperoxides, membrane-bound phospholipid-hydroperoxides, and dioxetanes, like those formed during the immune response to pathogens with reactive oxygen species (Belikov et al

In addition, cisplatin has been found to induce ferroptosis and apoptosis in CRC cells, and GSH deletion and GPX inactivation are important mechanisms for this occurrence

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Furthermore, it was well-tolerated in the studies examined (Li et al