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Presumably this reflects the fact that NADPH is generated by the proximal enzyme, G6PD, suggesting that the second dehydrogenase may not be necessary for cell integrity
Parry, R., Gifford, R

Role of catechins in chemosensitization, in Role of nutraceuticals in cancer chemosensitization (Elsevier), 169198

Recent studies identified a UV-independent pathway to melanoma carcinogenesis and implicated pheomelanins pro-oxidant properties that act through the generation of reactive oxygen species and/or the depletion of cellular antioxidants
