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By suppressing inflammasome assembly, melatonin limits inflammation via modulating pathways that relate to SIRT1, Wnt/ -catenin, long non-coding RNA and microRNA (Figure 6) (181)

Dron et al., 1990) including PATHOGENESIS-RELATED1 ( PR1 , Gomez et al., 2004b

Effect size analysis demonstrated a large between-group difference in GR activity (Hedges g=0.89), a small-to-negligible effect for GPx activity (g=0.11), and moderate effects for selected oxidative protein modification indices (g ranging from 0.38 to 0.59)

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