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MBP- or 6xHis-tagged ZADs were co-expressed in bacteria and purified on amylose or Ni-NTA resin, then visualized by SDS-PAGE

Thiazolidinedione compounds, clinically used as drugs for treating type 2 diabetes, have been found to selectively inhibit ACSL4, thereby inhibiting ferroptosis [125]

Follow-ups indicated that V LT (0.8+0.3 km-h1, p max .05), deltaV OBLA (1.1 +0.3 km-h-1, p max .01), and deltaTime to exhaustion (39.4 + 16.5 s, p max .05) were improved to across groups

Proc Natl Acad Sci U S A 101: 20402045, 2004 [DOI] [PMC free article] [PubMed] [Google Scholar] 171.Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, Harada T, Engel JD, and Yamamoto M