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[DOI] [PMC free article] [PubMed] [Google Scholar] Toews ML

2 The usefulness of applying evolutionary principles to medicine becomes apparent when we view the human body as what it truly is, a product of natural selection, with a particular focus on our reproduction, and not our health or well-being, being favoured by evolution

Furthermore, protease-activated receptor 2 (PAR2) signaling in melanocytes amplifies oxidative and inflammatory responses through the Akt/NF-B axis, elevating cytokine production and reducing antioxidant defenses, based on CAT and SOD activity, exacerbating skin inflammation 126