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A mediation analysis revealed that while a change in body weight was the primary contributing factor (72%) to the reduction in SBP, other factors, including estimated glomerular filtration rate and HbA 1c , were also involved to a lesser degree

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[18] Lactation studies demonstrate that maternal injections modestly elevate breast-milk B12 concentrations without adverse infant outcomes, supporting compatibility with breastfeeding while underscoring the need for maternal repletion to prevent neonatal deficiency

Moreover, free lipoic acid is rapidly eliminated from cells, so any increases in direct radical scavenging activity are unlikely to be sustained