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Abnormal mitochondrial function leads to reduced energy production associated with more cells undergoing apoptosis, increased ROS, and excessive excitability [91,92,93]

When glutathione neutralizes a free radical, it becomes oxidized and temporarily inactive

Since lactate is the end product of glycolysis, its production is primarily determined by the balance between glycolysis and mitochondrial oxidative phosphorylation

34 A recent analysis from the Cochrane Database of Systematic Reviews concludes that NAC likely has a modest beneficial effect on respiratory exacerbations and quality of life in patients with COPD, but that the effect tends be smaller in recent larger studies