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and, as an orphan drug, has been approved by the FDA for the treatment of malignant melanoma, chronic active hepatitis B, DiGeorge anomaly with immune defects, and hepatocellular carcinoma (Dominari et al

Exclusion criteria were: (1) case reports, conference abstracts, or editorials

Significantly, when combined with immune checkpoint inhibitors or indoleamine 2,3-dioxygenase (IDO) inhibitors, this combinatorial strategy shows strong efficacy in suppressing both the progression of primary tumors and distant metastases, thus presenting remarkable potential for transforming immunologically "cold" tumors into states responsive to immunotherapy [461, 462]

doi:10.1007/s00228-019-02741-x PubChem, Natinoal Library of Medicine