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Description
While considerable knowledge exists about TJ ultrastructure, relatively little is known about their patho-physiological regulation leading to local and/or systemic inflammation

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This work was supported by the BMBF/ZonMW program Innosystox (SysBioToP), and the DZ-foundation

This patient's young age and specific history of a childhood febrile heart illness point toward a post-inflammatory rheumatic etiology rather than age-related degenerative calcification
