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Preclinical studies support the integration of DNMTi, HDACi, or EZH2i with checkpoint inhibitors, as well as metabolic interventions targeting lactate or adenosine pathways, to improve immunotherapy efficacy and inform clinical translation
A major obstacle is the limited bioavailability of NAC, especially after oral intake, due to significant first-pass hepatic metabolism
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The magnitude varies based on lifestyle factors and individual biology
