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25 Patients diagnosed with vitamin B 12 deficiency whose history and physical examination do not suggest an obvious dietary or malabsorptive etiology should be tested for pernicious anemia with anti-intrinsic factor antibodies (positive predictive value = 95%), particularly if other autoimmune disorders are present

Patient History: Inform the healthcare provider of any history of "Leber's disease" (hereditary optic nerve atrophy) as high doses of Vitamin B12 can affect this condition

Can you overdose on B12 supplements

For adult males and females, they recommended 2.4 mcg/day, for pregnant females 2.6 mcg/day, and lactating females 2.8 mcg/day [5]