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and E.D

Zinc supplementation augmented TGF--induced Smad 2/3 signaling and thereby FoxP3 expression [168]

Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104