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Description
The principle behind the leaky gut theory is that endogenous (e.g., psychological stress, intestinal inflammation) and exogenous factors (e.g., diet, alcohol intake) can increase intestinal permeability, allowing the entrance of food antigens, commensal or pathogenic bacteria and bacterial components into the lamina propria and later on into the systemic circulation, provoking the systemic inflammation described in different disease conditions
Both in vitro and in vivo models exhibited similar inhibitory effects of curcumin in the activation of JNK, c-Jun and caspase-3
PMID 3543057
doi:10.1089/can.2016.0034 Freire RC, Cabrera-Abreu C, Milev R
