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These include vitamin B12 deficiency and malabsorption that is caused by the following medical conditions, according to the NIH [1]: Pernicious anemia Tropical sprue Pancreatic insufficiency Surgery in the gastrointestinal tract Certain medications Deficiency in the diet Side effects of B-12 injections Also, according to the NIH, vitamin B-12 injections have some potential side effects, including [1]: Diarrhea Itching Swelling Risk of allergic reaction and anaphylaxis Can Vitamins Aid in Weight Loss

LIF has been identified as a regulator of neuronal phenotype and a coordinator of glial and inflammatory cell responses in the CNS (reviewed in: 34,35 )

Overcoming Malabsorption: For conditions like pernicious anaemia, where the body cannot absorb B12 orally due to a lack of intrinsic factor, injections are the only effective treatment route