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However, whether these mechanistic overlaps translate into additive or synergistic clinical benefit in humans with obesity remains unproven, as deficiency-stratified, adequately powered trials with standardized exercise dose and clinically meaningful endpoints are lacking

David Aiello (BioAdvantex Pharma, Mississauga, Ontario, Canada) and Dr

Taken together, our findings suggest that miR-214 promotes the expression of ferroptosis genes ACSL4, SLC38A1, and PRKAA2 in hepatocytes

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