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Copper activates endoplasmic reticulum stress The endoplasmic reticulum (ER) is essential for hepatocytes to maintain lipid metabolism, with its regulatory roles including: (1) ER membrane-localized sterol regulatory element-binding proteins (SREBP-1c, SREBP-2), which regulate DNL-SREBP-1c primarily mediates fatty acid synthesis, while SREBP-2 controls cholesterol synthesis

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Increasing the storage duration from 1 to 5 days caused a moderate increase in edema while all other viability parameters of liver function and injury during simulated transplantation were largely unaffected by the substantially increased storage duration

10.1002/art.38884 22 ChoiH