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The Buthionine sulfoximine (BSO) irreversibly binds to -GCS, which is required during the condensation of glutamate and cysteine to produce GSH

doi: 10.1523/JNEUROSCI.1427-23.2023, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 15.Shan Y, Wang H, Yang Y, Wang J, Zhao W, Huang Y, et al

The crucial function of B12 in sleep latency is reinforced by a previous study that examined the impact of vitamin B12 supplementation on the sleepwake cycle of individuals with delayed sleep phase syndrome, showing a significant temporary improvement in the supplemented group [26]