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doi: 10.1007/s10334-011-0246-y
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A targeted and stable polymeric nanoformulation enhances systemic delivery of mRNA to tumors
Based on the above studies, we can speculate that regulating the hypoxic microenvironment and its associated HIF-1 upstream and downstream gene expression, such as VEGF, RIG-I and JAK/STAT3/HIF signaling pathways, may effectively reduce vascular inflammation and mitochondrial calcification in DM patients
