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Notably, our approach of rhGH + A administration at the end of puberty cannot be extrapolated to a large proportion of children with ISS before comparison is performed with the traditional prolonged rhGH treatment at lower classical doses starting at younger ages through larger trials

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Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans

Folate (vitamin B9) sits at the centre of this process