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For performance evaluation, a panel of known-mutagenic [ N -nitroso-dimethylamine (NDMA), N -nitroso-diethanolamine, N -nitroso-methylaniline, S N -nitroso-nornicotine, N-methyl-N-nitroso-2-propanamine] and reported non-mutagenic (methyl-t-butylnitrosamine, N -nitrosoproline) was tested, together with Nitrosamine Drug Substance-Related Impurities [ N -nitrosodesloratadine, N -nitrosofolic acid, N -nitrosofluoxetine (NFluo)] at a concentration range of 0.00510 mM

Similarly, it was also shown that in primary mesencephalic cultures, TPNA10168 upregulated HO-1 in astrocytes, thereby protecting dopaminergic neurons from neurodegeneration

LONDON/NEW YORK: CAMBRIDGE UNIVPRESS

Tirzepatide may not be removed from the FDA drug shortage list after all