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Figure 1 2 Pancreatic GABA in diabetes 2.1 GABA in the pancreatic islet GABA is present in assorted peripheral (non-CNS) tissues including pancreas, gonads, placenta, uterus, gastrointestinal tract, lymphatic and adrenal medulla ( Two GABA receptors are recognized

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They promote macrophage polarization toward the reparative M2 phenotype, suppress the local production of proinflammatory cytokines and ROS, and inhibit the activation of matrix metalloproteinases (MMPs) [126]

doi: 10.1038/nature10491 36 HuHHuangYLiJLiuRLiHCaiMet al