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Middle or moderate stage
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Celecoxib, a cyclooxygenase-2 inhibitor, improved upper gastrointestinal lesions in rheumatoid arthritis patients as assessed by endoscopic evaluation
Evening dosing encounters circadian suppression of autophagy (driven by PER2 gene expression), lower p53 protein levels due to peak MDM2 ubiquitin ligase activity, and potential interference from postprandial insulin signaling if dosed within 4 hours of eating
