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In COVID-19 patients, FeRD could trigger several clinical manifestations including (i) decrease functional hemoglobin (Hb), (ii) increase cellular iron overload, (iii) release free toxic heme into the circulation, (iv) manifest hypoxemia and systemic hypoxia, (v) reduce nitric oxide (NO) synthesis, (vi) activate coagulation pathway(s), (vii) trigger ferroptosis with OxS and lipid peroxidation, and (viii) induce mitochondrial degeneration 27,146

Based on above functional mechanisms of C10:2 in PVR, we found osthole significantly controlled cell cycle and blocked DNA synthesis to inhibit PASMCs proliferation by blocking PCNA, cyclinA and CDK2 in PASMCs

Atrial fibrillation after esophageal cancer surgery: an analysis of 207 consecutive patients

Diabetes 60 , 27302739 (2011)