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The researchers concluded that biologic therapies can be appropriate in patients with low BSA, particularly if they have high-impact site involvement and topical failure

Moreover, there were statistical differences between digit and knee neutrophils number ( P 80% degranulation) and decreased over time up to 80%, with a much more modest effect in the knee (25% inhibition

If your symptoms intensify rather than improve after two weeks, stop use and consult a dermatologist
Introduction to a generalized method for adaptive randomization in trials
