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10.1038/342440a0 [DOI] [PubMed] [Google Scholar] Naldini L., Vigna E., Narsimhan R

In humans, reduced stride length and walking capacity are strongly linked to mortality and morbidity 30

Most protocols last 46 weeks, but chronic issues may require cycling every few months

These tend to follow the same pattern as nausea, peaking during titration and decreasing over time
