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This reinforces a key difference in how pain is measured between human and animal models, as the conscious determination of a nociceptive threshold can be influenced by a large number of different factors, including psychological [28] and even placebo [29]

Baseline Characteristics by Nuclear Cataract Grade Table 3 presents the characteristics of participants grouped by nuclear (N) cataract grade (equal to N1 to N3): N1 (n=182, 47.4%), N2 (n=136, 35.4%), and N3 (n=66, 17.2%)

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Together, the results of these PCSK9 trials reinforce the lower is better hypothesis